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Structure paper

TitleAnti-LRP5/6 VHHs promote differentiation of Wnt-hypersensitive intestinal stem cells.
Journal, issue, pagesNat Commun, Vol. 10, Page 365-365, Year 2019
Publish dateJul 11, 2018 (structure data deposition date)
AuthorsFenderico, N. / van Scherpenzeel, R.C. / Goldflam, M. / Proverbio, D. / Jordens, I. / Kralj, T. / Stryeck, S. / Bass, T.Z. / Hermans, G. / Ullman, C. ...Fenderico, N. / van Scherpenzeel, R.C. / Goldflam, M. / Proverbio, D. / Jordens, I. / Kralj, T. / Stryeck, S. / Bass, T.Z. / Hermans, G. / Ullman, C. / Aastrup, T. / Gros, P. / Maurice, M.M.
External linksNat Commun / PubMed:30664649
MethodsX-ray diffraction
Resolution2.6 - 2.9 Å
Structure data

PDB-6h15:
Structure of LRP6 P3E3P4E4 in complex with VHH L-P2-B10
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

PDB-6h16:
Structure of LRP6 P3E3P4E4 in complex with VHH L-P2-D07
Method: X-RAY DIFFRACTION / Resolution: 2.9 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-CL:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-CA:
Unknown entry

Source
  • homo sapiens (human)
  • lama glama (llama)
KeywordsSIGNALING PROTEIN / Inhibitor / complex / signalling protein

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