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TitleDe novo design of potent and selective mimics of IL-2 and IL-15.
Journal, issue, pagesNature, Vol. 565, Page 186-191, Year 2019
Publish dateMay 16, 2018 (structure data deposition date)
AuthorsSilva, D.A. / Yu, S. / Ulge, U.Y. / Spangler, J.B. / Jude, K.M. / Labao-Almeida, C. / Ali, L.R. / Quijano-Rubio, A. / Ruterbusch, M. / Leung, I. ...Silva, D.A. / Yu, S. / Ulge, U.Y. / Spangler, J.B. / Jude, K.M. / Labao-Almeida, C. / Ali, L.R. / Quijano-Rubio, A. / Ruterbusch, M. / Leung, I. / Biary, T. / Crowley, S.J. / Marcos, E. / Walkey, C.D. / Weitzner, B.D. / Pardo-Avila, F. / Castellanos, J. / Carter, L. / Stewart, L. / Riddell, S.R. / Pepper, M. / Bernardes, G.J.L. / Dougan, M. / Garcia, K.C. / Baker, D.
External linksNature / PubMed:30626941
MethodsX-ray diffraction
Resolution1.999 - 2.516 Å
Structure data

PDB-6dg5:
Structure of a de novo designed Interleukin-2/Interleukin-15 mimetic complex with IL-2Rb and IL-2Rg
Method: X-RAY DIFFRACTION / Resolution: 2.516 Å

PDB-6dg6:
Structure of a de novo designed Interleukin-2/Interleukin-15 mimetic
Method: X-RAY DIFFRACTION / Resolution: 1.999 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-HOH:
WATER

Source
  • synthetic construct (others)
  • mus musculus (house mouse)
KeywordsBIOSYNTHETIC PROTEIN/Protein Binding / cytokine mimetic / cytokine receptor complex / BIOSYNTHETIC PROTEIN / BIOSYNTHETIC PROTEIN-Protein Binding complex

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