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Structure paper

TitleA T-cell receptor escape channel allows broad T-cell response to CD1b and membrane phospholipids.
Journal, issue, pagesNat Commun, Vol. 10, Page 56-56, Year 2019
Publish dateMar 26, 2018 (structure data deposition date)
AuthorsShahine, A. / Reinink, P. / Reijneveld, J.F. / Gras, S. / Holzheimer, M. / Cheng, T.Y. / Minnaard, A.J. / Altman, J.D. / Lenz, S. / Prandi, J. ...Shahine, A. / Reinink, P. / Reijneveld, J.F. / Gras, S. / Holzheimer, M. / Cheng, T.Y. / Minnaard, A.J. / Altman, J.D. / Lenz, S. / Prandi, J. / Kubler-Kielb, J. / Moody, D.B. / Rossjohn, J. / Van Rhijn, I.
External linksNat Commun / PubMed:30610190
MethodsX-ray diffraction
Resolution1.7 - 2.4 Å
Structure data

PDB-6cug:
Crystal structure of BC8B TCR-CD1b-PC complex
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

PDB-6cuh:
Crystal structure of the unliganded BC8B TCR
Method: X-RAY DIFFRACTION / Resolution: 2.01 Å

PDB-6d64:
Crystal Structure of Human CD1b in Complex with POPC
Method: X-RAY DIFFRACTION / Resolution: 1.7 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-CUY:
tetracosyl octadecanoate

ChemComp-POV:
(2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate / phospholipid*YM

ChemComp-CL:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-PEG:
DI(HYDROXYETHYL)ETHER

ChemComp-PO4:
PHOSPHATE ION

ChemComp-ACT:
ACETATE ION

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-NA:
Unknown entry

ChemComp-IOD:
IODIDE ION

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / T cell receptor / antigen presenting molecule / CD1b / PC / phosphatidylcholine / TCR / BC8B / CD1 / POPC

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