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-Structure paper
Title | Identification of BR101549 as a lead candidate of non-TZD PPAR gamma agonist for the treatment of type 2 diabetes: Proof-of-concept evaluation and SAR. |
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Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 29, Page 631-637, Year 2019 |
Publish date | Oct 19, 2018 (structure data deposition date) |
![]() | Choung, W. / Jung, H.J. / Yang, D. / Nam, E.H. / Choi, H. / Lee, B.R. / Park, M. / Jang, S.M. / Lim, J.S. / Kim, W.S. ...Choung, W. / Jung, H.J. / Yang, D. / Nam, E.H. / Choi, H. / Lee, B.R. / Park, M. / Jang, S.M. / Lim, J.S. / Kim, W.S. / Kim, K.H. / Chin, J. / Jung, K. / Lee, G. / Hong, E. / Jang, T.H. / Myung, J. / Kim, S.H. |
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Methods | X-ray diffraction |
Resolution | 2.408 Å |
Structure data | ![]() PDB-6ilq: |
Chemicals | ![]() ChemComp-AE0: ![]() ChemComp-HOH: |
Source |
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![]() | NUCLEAR PROTEIN / peroxisome proliferator-activated receptor-g(PPAR-g) / transcription factor / ligand-binding domain / Steroid receptor Coactivator-1 |