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Structure paper

TitleStructural basis for the specificity of renin-mediated angiotensinogen cleavage.
Journal, issue, pagesJ. Biol. Chem., Vol. 294, Page 2353-2364, Year 2019
Publish dateOct 17, 2016 (structure data deposition date)
AuthorsYan, Y. / Zhou, A. / Carrell, R.W. / Read, R.J.
External linksJ. Biol. Chem. / PubMed:30563843
MethodsX-ray diffraction
Resolution2.3 - 2.97 Å
Structure data

PDB-5m3x:
Crystal structure of human angiotensin I-deleted angiotensinogen
Method: X-RAY DIFFRACTION / Resolution: 2.63 Å

PDB-5m3y:
Crystal structure of human glycosylated angiotensinogen
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

PDB-6i3f:
Crystal structure of the complex of human angiotensinogen and renin at 2.55 Angstrom
Method: X-RAY DIFFRACTION / Resolution: 2.55 Å

PDB-6i3i:
Crystal structure of reactive center loop (RCL) cleaved angiotensinogen
Method: X-RAY DIFFRACTION / Resolution: 2.97 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-SO4:
SULFATE ION

ChemComp-GOL:
GLYCEROL

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

Source
  • homo sapiens (human)
KeywordsSerine protease inhibitor / spent angiotensinogen / angiotensin I-deleted angiotensinogen / glycosylated / human angiotensiogen / HYDROLASE / angiotensinogen / renin / glycosylation / complex / HORMONE / reactive center loop

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