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TitleDefining the human C2H2 zinc finger degrome targeted by thalidomide analogs through CRBN.
Journal, issue, pagesScience, Vol. 362, Page eaat0572-, Year 2018
Publish dateJul 9, 2018 (structure data deposition date)
AuthorsSievers, Q.L. / Petzold, G. / Bunker, R.D. / Renneville, A. / Slabicki, M. / Liddicoat, B.J. / Abdulrahman, W. / Mikkelsen, T. / Ebert, B.L. / Thoma, N.H.
External linksScience / PubMed:30385546
MethodsX-ray diffraction
Resolution3.25 - 4.25 Å
Structure data

PDB-6h0f:
Structure of DDB1-CRBN-pomalidomide complex bound to IKZF1(ZF2)
Method: X-RAY DIFFRACTION / Resolution: 3.25 Å

PDB-6h0g:
Structure of the DDB1-CRBN-pomalidomide complex bound to ZNF692(ZF4)
Method: X-RAY DIFFRACTION / Resolution: 4.25 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-Y70:
S-Pomalidomide

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsSIGNALING PROTEIN / E3 ubiquitin ligase / drug mediated protein-interaction / targeted protein degradation

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