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Structure paper

TitleStructural reorganization of SHP2 by oncogenic mutations and implications for oncoprotein resistance to allosteric inhibition.
Journal, issue, pagesNat Commun, Vol. 9, Page 4508-4508, Year 2018
Publish dateMar 17, 2018 (structure data deposition date)
AuthorsLaRochelle, J.R. / Fodor, M. / Vemulapalli, V. / Mohseni, M. / Wang, P. / Stams, T. / LaMarche, M.J. / Chopra, R. / Acker, M.G. / Blacklow, S.C.
External linksNat Commun / PubMed:30375388
MethodsX-ray diffraction
Resolution2.62 - 2.75 Å
Structure data

PDB-6crf:
Crystal Structure of Shp2 E76K GOF Mutant in the Open Conformation
Method: X-RAY DIFFRACTION / Resolution: 2.62 Å

PDB-6crg:
Crystal Structure of Shp2 E76K GOF Mutant in complex with SHP099
Method: X-RAY DIFFRACTION / Resolution: 2.75 Å

Chemicals

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

ChemComp-5OD:
6-(4-azanyl-4-methyl-piperidin-1-yl)-3-[2,3-bis(chloranyl)phenyl]pyrazin-2-amine

ChemComp-SO4:
SULFATE ION

Source
  • homo sapiens (human)
KeywordsHYDROLASE / SHP2 / PTPN11 / PROTEIN TYROSINE PHOSPHATASE / E76K / Gain of Function Mutant / Open Conformation / PHOSPHATASE / HYDROLASE/HYDROLASE INHIBITOR / ALLOSTERIC INHIBITOR / HYDROLASE-HYDROLASE INHIBITOR COMPLEX

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