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Structure paper

TitleBRCT domains of the DNA damage checkpoint proteins TOPBP1/Rad4 display distinct specificities for phosphopeptide ligands.
Journal, issue, pagesElife, Vol. 7, Year 2018
Publish dateSep 12, 2018 (structure data deposition date)
AuthorsDay, M. / Rappas, M. / Ptasinska, K. / Boos, D. / Oliver, A.W. / Pearl, L.H.
External linksElife / PubMed:30295604
MethodsX-ray diffraction
Resolution1.77018592355 - 2.33003812226 Å
Structure data

PDB-6hm3:
Crystal structure of Rad4 BRCT1,2 in complex with a Sld3 phosphopeptide
Method: X-RAY DIFFRACTION / Resolution: 1.77263620528 Å

PDB-6hm4:
Crystal structure of Rad4 BRCT1,2 in complex with a Mdb1 phosphopeptide
Method: X-RAY DIFFRACTION / Resolution: 1.77018592355 Å

PDB-6hm5:
Crystal structure of TOPBP1 BRCT0,1,2 in complex with a RAD9 phosphopeptide
Method: X-RAY DIFFRACTION / Resolution: 2.33003812226 Å

Chemicals

ChemComp-GOL:
GLYCEROL

ChemComp-CA:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-ACT:
ACETATE ION

ChemComp-EDO:
1,2-ETHANEDIOL

Source
  • schizosaccharomyces pombe (strain 972 / atcc 24843) (yeast)
  • schizosaccharomyces pombe (fission yeast)
  • gallus gallus (chicken)
  • homo sapiens (human)
KeywordsCELL CYCLE / BRCT domain phosphopeptide recognition

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