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Structure paper

TitleBypassing a 8,5'-cyclo-2'-deoxyadenosine lesion by human DNA polymerase eta at atomic resolution.
Journal, issue, pagesProc. Natl. Acad. Sci. U.S.A., Vol. 115, Page 10660-10665, Year 2018
Publish dateAug 20, 2018 (structure data deposition date)
AuthorsWeng, P.J. / Gao, Y. / Gregory, M.T. / Wang, P. / Wang, Y. / Yang, W.
External linksProc. Natl. Acad. Sci. U.S.A. / PubMed:30275308
MethodsX-ray diffraction
Resolution1.75 - 3.4 Å
Structure data

PDB-6m7o:
Human DNA polymerase eta ternary complex with Mn2+ and dTMPNPP oppositing cdA
Method: X-RAY DIFFRACTION / Resolution: 3 Å

PDB-6m7p:
Human DNA polymerase eta extension complex with cdA at the -2 position
Method: X-RAY DIFFRACTION / Resolution: 1.75 Å

PDB-6m7t:
Human DNA polymerase eta in a non-productive ternary complex with Ca2+ and dTTP oppositing cdA
Method: X-RAY DIFFRACTION / Resolution: 2.8 Å

PDB-6m7u:
Human DNA polymerase eta in a non-productive ternary complex with Mg2+ and dTMPNPP oppositing cdA
Method: X-RAY DIFFRACTION / Resolution: 3.4 Å

PDB-6m7v:
Human DNA polymerase eta extension complex with cdA at the -1 position
Method: X-RAY DIFFRACTION / Resolution: 3.062 Å

Chemicals

ChemComp-MN:
Unknown entry

ChemComp-1FZ:
5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]thymidine

ChemComp-HOH:
WATER

ChemComp-DZ4:
2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]adenosine

ChemComp-MG:
Unknown entry

ChemComp-GOL:
GLYCEROL

ChemComp-NI:
NICKEL (II) ION

ChemComp-TTP:
THYMIDINE-5'-TRIPHOSPHATE

ChemComp-CA:
Unknown entry

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-CL:
Unknown entry

Source
  • homo sapiens (human)
KeywordsTRANSFERASE/DNA / TRANSLESION SYNTHESIS / cdA / DNA BINDING PROTEIN / TRANSFERASE-DNA complex / HUMAN DNA POLYMERSE ETA cdA

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