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TitleDirect induction of microtubule branching by microtubule nucleation factor SSNA1.
Journal, issue, pagesNat Cell Biol, Vol. 20, Issue 10, Page 1172-1180, Year 2018
Publish dateSep 24, 2018
AuthorsNirakar Basnet / Hana Nedozralova / Alvaro H Crevenna / Satish Bodakuntla / Thomas Schlichthaerle / Michael Taschner / Giovanni Cardone / Carsten Janke / Ralf Jungmann / Maria M Magiera / Christian Biertümpfel / Naoko Mizuno /
PubMed AbstractMicrotubules are central elements of the eukaryotic cytoskeleton that often function as part of branched networks. Current models for branching include nucleation of new microtubules from severed ...Microtubules are central elements of the eukaryotic cytoskeleton that often function as part of branched networks. Current models for branching include nucleation of new microtubules from severed microtubule seeds or from γ-tubulin recruited to the side of a pre-existing microtubule. Here, we found that microtubules can be directly remodelled into branched structures by the microtubule-remodelling factor SSNA1 (also known as NA14 or DIP13). The branching activity of SSNA1 relies on its ability to self-assemble into fibrils in a head-to-tail fashion. SSNA1 fibrils guide protofilaments of a microtubule to split apart to form daughter microtubules. We further found that SSNA1 localizes at axon branching sites and has a key role in neuronal development. SSNA1 mutants that abolish microtubule branching in vitro also fail to promote axon development and branching when overexpressed in neurons. We have, therefore, discovered a mechanism for microtubule branching and implicated its role in neuronal development.
External linksNat Cell Biol / PubMed:30250060 / PubMed Central
MethodsEM (helical sym.)
Resolution6.1 Å
Structure data

EMDB-4188:
Cryo-EM structure of microtubule co-polymerized with SSNA1.
Method: EM (helical sym.) / Resolution: 6.1 Å

Source
  • Chlamydo

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