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TitleMode of Action of Kanglemycin A, an Ansamycin Natural Product that Is Active against Rifampicin-Resistant Mycobacterium tuberculosis.
Journal, issue, pagesMol. Cell, Vol. 72, Page 263-274.e5, Year 2018
Publish dateMar 26, 2018 (structure data deposition date)
AuthorsMosaei, H. / Molodtsov, V. / Kepplinger, B. / Harbottle, J. / Moon, C.W. / Jeeves, R.E. / Ceccaroni, L. / Shin, Y. / Morton-Laing, S. / Marrs, E.C.L. ...Mosaei, H. / Molodtsov, V. / Kepplinger, B. / Harbottle, J. / Moon, C.W. / Jeeves, R.E. / Ceccaroni, L. / Shin, Y. / Morton-Laing, S. / Marrs, E.C.L. / Wills, C. / Clegg, W. / Yuzenkova, Y. / Perry, J.D. / Bacon, J. / Errington, J. / Allenby, N.E.E. / Hall, M.J. / Murakami, K.S. / Zenkin, N.
External linksMol. Cell / PubMed:30244835
MethodsX-ray diffraction
Resolution2.994 - 4.104 Å
Structure data

PDB-6cuu:
Thermus thermophiles RNA polymerase in complex with promoter DNA and antibiotic Kanglemycin A
Method: X-RAY DIFFRACTION / Resolution: 2.994 Å

PDB-6cux:
Escherichia coli RpoB S531L mutant RNA polymerase holoenzyme in complex with Kanglemycin A
Method: X-RAY DIFFRACTION / Resolution: 4.104 Å

Chemicals

ChemComp-KNG:
Kanglemycin A

ChemComp-ZN:
Unknown entry

ChemComp-MG:
Unknown entry

Source
  • thermus thermophilus (strain hb27 / atcc baa-163 / dsm 7039) (bacteria)
  • bacillus subtilis (bacteria)
  • escherichia coli (strain k12) (bacteria)
Keywordstranscription/dna/antibiotic / RNA polymerase / Kanglemycin A / transcription inhibitor / TRANSCRIPTION / transcription-dna-antibiotic complex / transcription/antibiotic / Bacterial RNA polymerase / transcription-transcription inhibitor complex / transcription-antibiotic complex

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