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TitleStructure of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase-dihydropteroate synthase fromPlasmodium vivaxsheds light on drug resistance
Journal, issue, pagesJ. Biol. Chem., Vol. 293, Page 14962-14972, Year 2018
Publish dateJan 27, 2018 (structure data deposition date)
AuthorsYogavel, M. / Nettleship, J.E. / Sharma, A. / Harlos, K. / Jamwal, A. / Chaturvedi, R. / Sharma, M. / Jain, V. / Chhibber-Goel, J.
External linksJ. Biol. Chem. / PubMed:30104413
MethodsX-ray diffraction
Resolution2.9 Å
Structure data

PDB-5z79:
Crystal Structure Analysis of the HPPK-DHPS in complex with substrates
Method: X-RAY DIFFRACTION / Resolution: 2.9 Å

Chemicals

ChemComp-HH2:
6-HYDROXYMETHYLPTERIN-DIPHOSPHATE

ChemComp-APC:
DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER / AMP-CPP, energy-carrying molecule analogue*YM

ChemComp-PAB:
4-AMINOBENZOIC ACID

ChemComp-MG:
Unknown entry

ChemComp-PE0:
PTERINE

ChemComp-5AD:
5'-DEOXYADENOSINE

ChemComp-HOH:
WATER

Source
  • plasmodium vivax (malaria parasite P. vivax)
KeywordsTRANSFERASE / Bifunctional / Malaria Pterin / Substrates

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