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Structure paper

TitleStructural basis for selective inhibition of immunoglobulin E-receptor interactions by an anti-IgE antibody.
Journal, issue, pagesSci Rep, Vol. 8, Page 11548-11548, Year 2018
Publish dateNov 13, 2017 (structure data deposition date)
AuthorsChen, J.B. / Ramadani, F. / Pang, M.O.Y. / Beavil, R.L. / Holdom, M.D. / Mitropoulou, A.N. / Beavil, A.J. / Gould, H.J. / Chang, T.W. / Sutton, B.J. ...Chen, J.B. / Ramadani, F. / Pang, M.O.Y. / Beavil, R.L. / Holdom, M.D. / Mitropoulou, A.N. / Beavil, A.J. / Gould, H.J. / Chang, T.W. / Sutton, B.J. / McDonnell, J.M. / Davies, A.M.
External linksSci Rep / PubMed:30069035
MethodsX-ray diffraction
Resolution2.4 - 3.7 Å
Structure data

PDB-6eyn:
Structure of the 8D6 (anti-IgE) Fab
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

PDB-6eyo:
Structure of extended IgE-Fc in complex with two anti-IgE Fabs
Method: X-RAY DIFFRACTION / Resolution: 3.7 Å

Chemicals

ChemComp-PEG:
DI(HYDROXYETHYL)ETHER

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / Immunoglobulin E / Fab / antibody / complex

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