タイトル | Structural basis for the inhibition of poxvirus assembly by the antibiotic rifampicin. |
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ジャーナル・号・ページ | Proc. Natl. Acad. Sci. U.S.A., Vol. 115, Page 8424-8429, Year 2018 |
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掲載日 | 2017年10月25日 (構造データの登録日) |
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著者 | Garriga, D. / Headey, S. / Accurso, C. / Gunzburg, M. / Scanlon, M. / Coulibaly, F. |
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リンク | Proc. Natl. Acad. Sci. U.S.A. / PubMed:30068608 |
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手法 | X線回折 |
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解像度 | 2.55 - 3.21 Å |
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構造データ | PDB-6beb: Crystal structure of VACV D13 in complex with Rifamycin SV 手法: X-RAY DIFFRACTION / 解像度: 2.55 Å PDB-6bec: Crystal structure of VACV D13 in complex with Rifabutin 手法: X-RAY DIFFRACTION / 解像度: 2.91 Å PDB-6bed: Crystal structure of VACV D13 in complex with Rifampicin 手法: X-RAY DIFFRACTION / 解像度: 2.75 Å PDB-6bee: Crystal structure of VACV D13 in complex with Rifaximin 手法: X-RAY DIFFRACTION / 解像度: 3.11 Å PDB-6bef: Crystal structure of VACV D13 in complex with 3-formyl rifamycin SV 手法: X-RAY DIFFRACTION / 解像度: 3.21 Å PDB-6beg: Crystal structure of VACV D13 F486A mutant 手法: X-RAY DIFFRACTION / 解像度: 3.1 Å PDB-6beh: Crystal structure of VACV D13 in complex with Rifapentine 手法: X-RAY DIFFRACTION / 解像度: 3.0 Å PDB-6bei: Crystal structure of VACV D13 in its apo (unbound) form 手法: X-RAY DIFFRACTION / 解像度: 2.81 Å |
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化合物 | ChemComp-RXM: (2S,16Z,18E,20S,21S,22R,23R,24R,25S,26R,27S,28E)-5,6,21,23-tetrahydroxy-27-methoxy-2,4,11,16,20,22,24,26-octamethyl-1,1 / 抗生剤*YM
ChemComp-3YI: (2S,12Z,14E,16S,17S,18R,19R,20R,21S,22R,23S,24E)-8-formyl-5,6,9,17,19-pentahydroxy-23-methoxy-2,4,12,16,18,20,22-heptam
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由来 | vaccinia virus wr (ウイルス) vaccinia virus (strain western reserve) (ウイルス)
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キーワード | VIRAL PROTEIN / poxvirus / assembly / scaffolding protein / Rifampicin resistance protein / immature virion / RIFAMPICIN RESISTANCE |
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