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Structure paper

TitleDesigned peptides that assemble into cross-alpha amyloid-like structures.
Journal, issue, pagesNat. Chem. Biol., Vol. 14, Page 870-875, Year 2018
Publish dateJan 13, 2018 (structure data deposition date)
AuthorsZhang, S.Q. / Huang, H. / Yang, J. / Kratochvil, H.T. / Lolicato, M. / Liu, Y. / Shu, X. / Liu, L. / DeGrado, W.F.
External linksNat. Chem. Biol. / PubMed:30061717
MethodsX-ray diffraction
Resolution1.6 - 3.7 Å
Structure data

PDB-6c4x:
Cross-alpha Amyloid-like Structure alphaAmmem
Method: X-RAY DIFFRACTION / Resolution: 3.55 Å

PDB-6c4y:
Cross-alpha Amyloid-like Structure alphaAmG
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

PDB-6c4z:
Cross-alpha Amyloid-like Structure alphaAmG - low resolution
Method: X-RAY DIFFRACTION / Resolution: 3.3 Å

PDB-6c50:
Cross-alpha Amyloid-like Structure alphaAmS
Method: X-RAY DIFFRACTION / Resolution: 2.503 Å

PDB-6c51:
Cross-alpha Amyloid-like Structure alphaAmL
Method: X-RAY DIFFRACTION / Resolution: 2 Å

PDB-6c52:
Cross-alpha Amyloid-like Structure alphaTet
Method: X-RAY DIFFRACTION / Resolution: 1.6 Å

PDB-6d02:
Cross-alpha Amyloid-like Structure alphaAmL, 2nd form
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

PDB-6o3n:
Cross-alpha Amyloid-like Structure alphaAmA
Method: X-RAY DIFFRACTION / Resolution: 3.7 Å

Chemicals

ChemComp-MPD:
(4S)-2-METHYL-2,4-PENTANEDIOL / precipitant*YM

ChemComp-ZN:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-FMT:
FORMIC ACID

ChemComp-PO4:
PHOSPHATE ION

ChemComp-GOL:
GLYCEROL

ChemComp-CO3:
CARBONATE ION

Source
  • synthetic construct (others)
  • synthetic (others)
KeywordsDE NOVO PROTEIN / Protein Design / Cross-alpha Amyloid / alpha-amyloid / protein desidn / de Novo / coiled-coil / fabril / De Novo Design / fibril

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