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-Structure paper
Title | Surface Probing by Fragment-Based Screening and Computational Methods Identifies Ligandable Pockets on the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase. |
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Journal, issue, pages | J. Med. Chem., Vol. 61, Page 7387-7393, Year 2018 |
Publish date | May 27, 2018 (structure data deposition date) |
![]() | Lucas, X. / Van Molle, I. / Ciulli, A. |
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Methods | X-ray diffraction |
Resolution | 1.75 - 2.755 Å |
Structure data | ![]() PDB-6gmn: ![]() PDB-6gmq: ![]() PDB-6gmr: ![]() PDB-6gmx: |
Chemicals | ![]() ChemComp-ACT: ![]() ChemComp-F4E: ![]() ChemComp-HOH: ![]() ChemComp-F4K: ![]() ChemComp-IPA: ![]() ChemComp-SO4: ![]() ChemComp-GOL: ![]() ChemComp-F7B: |
Source |
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![]() | ONCOPROTEIN / E3 ubiquitin ligase / tumor supressor / PROTAC / fragment-based drug discovery / LIGASE / von Hippel Lindau tumor supressor / PROTOC |