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TitleA human anti-IL-2 antibody that potentiates regulatory T cells by a structure-based mechanism.
Journal, issue, pagesNat. Med., Vol. 24, Page 1005-1014, Year 2018
Publish dateFeb 15, 2017 (structure data deposition date)
AuthorsTrotta, E. / Bessette, P.H. / Silveria, S.L. / Ely, L.K. / Jude, K.M. / Le, D.T. / Holst, C.R. / Coyle, A. / Potempa, M. / Lanier, L.L. ...Trotta, E. / Bessette, P.H. / Silveria, S.L. / Ely, L.K. / Jude, K.M. / Le, D.T. / Holst, C.R. / Coyle, A. / Potempa, M. / Lanier, L.L. / Garcia, K.C. / Crellin, N.K. / Rondon, I.J. / Bluestone, J.A.
External linksNat. Med. / PubMed:29942088
MethodsX-ray diffraction
Resolution2.747 Å
Structure data

PDB-5utz:
Human IL-2/Fab complex
Method: X-RAY DIFFRACTION / Resolution: 2.747 Å

Chemicals

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsCYTOKINE/IMMUNE SYSTEM / cytokine / Fab / complex / CYTOKINE-IMMUNE SYSTEM complex

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