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TitleCrystal Structures of Spleen Tyrosine Kinase in Complex with Two Novel 4-Aminopyrido[4,3-d] Pyrimidine Derivative Inhibitors.
Journal, issue, pagesMol. Cells, Vol. 41, Page 545-552, Year 2018
Publish dateAug 9, 2017 (structure data deposition date)
AuthorsLee, S.J. / Choi, J.S. / Bong, S.M. / Hwang, H.J. / Lee, J. / Song, H.J. / Kim, J.H. / Koh, J.S. / Lee, B.I.
External linksMol. Cells / PubMed:29890824
MethodsX-ray diffraction
Resolution1.8 - 2.14 Å
Structure data

PDB-5y5t:
Crystal structures of spleen tyrosine kinase in complex with a novel inhibitor
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

PDB-5y5u:
Crystal structures of spleen tyrosine kinase in complex with a novel inhibitor
Method: X-RAY DIFFRACTION / Resolution: 2.14 Å

Chemicals

ChemComp-8OR:
2-[[(1S,2S)-2-azanylcyclohexyl]amino]-4-[(4-methylsulfonylphenyl)amino]-6H-pyrido[4,3-d]pyrimidin-5-one

ChemComp-HOH:
WATER

ChemComp-8OU:
4-[(1-methylindazol-5-yl)amino]-2-(4-oxidanylpiperidin-1-yl)-8H-pyrido[4,3-d]pyrimidin-5-one

Source
  • homo sapiens (human)
KeywordsTRANSFERASE/TRANSFERASE INHIBITOR / Inhibitor / Spleen Tyrosine Kinase / human kinase / drug discovery / TRANSFERASE / TRANSFERASE-TRANSFERASE INHIBITOR complex

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