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TitlePotent and selective antitumor activity of a T cell-engaging bispecific antibody targeting a membrane-proximal epitope of ROR1.
Journal, issue, pagesProc. Natl. Acad. Sci. U.S.A., Vol. 115, Page E5467-E5476, Year 2018
Publish dateOct 12, 2017 (structure data deposition date)
AuthorsQi, J. / Li, X. / Peng, H. / Cook, E.M. / Dadashian, E.L. / Wiestner, A. / Park, H. / Rader, C.
External linksProc. Natl. Acad. Sci. U.S.A. / PubMed:29844189
MethodsX-ray diffraction
Resolution1.62 - 1.95 Å
Structure data

PDB-6ba5:
Potent and Selective Antitumor Activity of a T-Cell Engaging Bispecific Antibody Targeting a Membrane-Proximal Epitope of ROR1
Method: X-RAY DIFFRACTION / Resolution: 1.62 Å

PDB-6ban:
Potent and Selective Antitumor Activity of a T-Cell Engaging Bispecific Antibody Targeting a Membrane-Proximal Epitope of ROR1
Method: X-RAY DIFFRACTION / Resolution: 1.95 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / Single chain Fv / ScFv / Antibody / ROR1 / Kringle domain / receptor tyrosine kinase-like orphan receptor / Phage display

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