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Structure paper

TitleMolecular basis for the loss-of-function effects of the Alzheimer's disease-associated R47H variant of the immune receptor TREM2.
Journal, issue, pagesJ. Biol. Chem., Vol. 293, Page 12634-12646, Year 2018
Publish dateDec 23, 2016 (structure data deposition date)
AuthorsSudom, A. / Talreja, S. / Danao, J. / Bragg, E. / Kegel, R. / Min, X. / Richardson, J. / Zhang, Z. / Sharkov, N. / Marcora, E. ...Sudom, A. / Talreja, S. / Danao, J. / Bragg, E. / Kegel, R. / Min, X. / Richardson, J. / Zhang, Z. / Sharkov, N. / Marcora, E. / Thibault, S. / Bradley, J. / Wood, S. / Lim, A.C. / Chen, H. / Wang, S. / Foltz, I.N. / Sambashivan, S. / Wang, Z.
External linksJ. Biol. Chem. / PubMed:29794134
MethodsX-ray diffraction
Resolution1.8 - 2.20002253654 Å
Structure data

PDB-5ud7:
Crystal Structure of Wild-Type Ig-like Domain
Method: X-RAY DIFFRACTION / Resolution: 2.20002253654 Å

PDB-5ud8:
Crystal Structure of Mutant Ig-like Domain
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

PDB-6b8o:
WT Ig-like V Domain with Phosphatidylserine
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-IOD:
IODIDE ION

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-PSF:
1,2-DICAPROYL-SN-PHOSPHATIDYL-L-SERINE

Source
  • homo sapiens (human)
KeywordsSIGNALING PROTEIN / Ig-like domain / receptor / lipid binding / immunoregulatory / IMMUNE SYSTEM / Membrane receptor

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