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-Structure paper
Title | Molecular basis for the loss-of-function effects of the Alzheimer's disease-associated R47H variant of the immune receptor TREM2. |
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Journal, issue, pages | J. Biol. Chem., Vol. 293, Page 12634-12646, Year 2018 |
Publish date | Dec 23, 2016 (structure data deposition date) |
Authors | Sudom, A. / Talreja, S. / Danao, J. / Bragg, E. / Kegel, R. / Min, X. / Richardson, J. / Zhang, Z. / Sharkov, N. / Marcora, E. ...Sudom, A. / Talreja, S. / Danao, J. / Bragg, E. / Kegel, R. / Min, X. / Richardson, J. / Zhang, Z. / Sharkov, N. / Marcora, E. / Thibault, S. / Bradley, J. / Wood, S. / Lim, A.C. / Chen, H. / Wang, S. / Foltz, I.N. / Sambashivan, S. / Wang, Z. |
External links | J. Biol. Chem. / PubMed:29794134 |
Methods | X-ray diffraction |
Resolution | 1.8 - 2.20002253654 Å |
Structure data | PDB-5ud7: PDB-5ud8: PDB-6b8o: |
Chemicals | ChemComp-NAG: ChemComp-IOD: ChemComp-SO4: ChemComp-HOH: ChemComp-EDO: ChemComp-PSF: |
Source |
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Keywords | SIGNALING PROTEIN / Ig-like domain / receptor / lipid binding / immunoregulatory / IMMUNE SYSTEM / Membrane receptor |