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Structure paper

TitleStructure-Guided Combinatorial Engineering Facilitates Affinity and Specificity Optimization of Anti-CD81 Antibodies.
Journal, issue, pagesJ. Mol. Biol., Vol. 430, Page 2139-2152, Year 2018
Publish dateSep 21, 2017 (structure data deposition date)
AuthorsNelson, B. / Adams, J. / Kuglstatter, A. / Li, Z. / Harris, S.F. / Liu, Y. / Bohini, S. / Ma, H. / Klumpp, K. / Gao, J. / Sidhu, S.S.
External linksJ. Mol. Biol. / PubMed:29778602
MethodsX-ray diffraction
Resolution2.15 - 2.82 Å
Structure data

PDB-6ejg:
CRYSTAL STRUCTURE OF HUMAN CD81 LARGE EXTRACELLULAR LOOP IN COMPLEX WITH SINGLE CHAIN FV FRAGMENT 4
Method: X-RAY DIFFRACTION / Resolution: 2.82 Å

PDB-6ejm:
CRYSTAL STRUCTURE OF HUMAN CD81 LARGE EXTRACELLULAR LOOP IN COMPLEX WITH SINGLE CHAIN FV FRAGMENT 5
Method: X-RAY DIFFRACTION / Resolution: 2.15 Å

PDB-6ek2:
CRYSTAL STRUCTURE OF HUMAN CD81 LARGE EXTRACELLULAR LOOP IN COMPLEX WITH SINGLE CHAIN FV FRAGMENT 10
Method: X-RAY DIFFRACTION / Resolution: 2.65 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • mus musculus (house mouse)
KeywordsCELL ADHESION / HELICAL BUNDLE / ANTIBODY-ANTIGEN COMPLEX

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