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TitleIdentification of a peptide inhibitor for the histone methyltransferase WHSC1.
Journal, issue, pagesPLoS ONE, Vol. 13, Page e0197082-e0197082, Year 2018
Publish dateFeb 12, 2018 (structure data deposition date)
AuthorsMorrison, M.J. / Boriack-Sjodin, P.A. / Swinger, K.K. / Wigle, T.J. / Sadalge, D. / Kuntz, K.W. / Scott, M.P. / Janzen, W.P. / Chesworth, R. / Duncan, K.W. ...Morrison, M.J. / Boriack-Sjodin, P.A. / Swinger, K.K. / Wigle, T.J. / Sadalge, D. / Kuntz, K.W. / Scott, M.P. / Janzen, W.P. / Chesworth, R. / Duncan, K.W. / Harvey, D.M. / Lampe, J.W. / Mitchell, L.H. / Copeland, R.A.
External linksPLoS ONE / PubMed:29742153
MethodsX-ray diffraction
Resolution1.61 Å
Structure data

PDB-6cen:
Crystal Structure of WHSC1L1 in Complex with Inhibitor PEP21
Method: X-RAY DIFFRACTION / Resolution: 1.61 Å

Chemicals

ChemComp-SAM:
S-ADENOSYLMETHIONINE

ChemComp-ZN:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE/INHIBITOR / Histone-lysine N-methyltransferase NSD3 / TRANSFERASE / TRANSFERASE-INHIBITOR complex

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