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Structure paper

TitlePatient-derived mutations within the N-terminal domains of p85 alpha impact PTEN or Rab5 binding and regulation.
Journal, issue, pagesSci Rep, Vol. 8, Page 7108-7108, Year 2018
Publish dateApr 25, 2018 (structure data deposition date)
AuthorsMellor, P. / Marshall, J.D.S. / Ruan, X. / Whitecross, D.E. / Ross, R.L. / Knowles, M.A. / Moore, S.A. / Anderson, D.H.
External linksSci Rep / PubMed:29740032
MethodsX-ray diffraction
Resolution2.203 - 2.7 Å
Structure data

PDB-6d81:
Structure of the Bovine p85a BH domain
Method: X-RAY DIFFRACTION / Resolution: 2.248 Å

PDB-6d82:
Structure of the Bovine p85a BH domain
Method: X-RAY DIFFRACTION / Resolution: 2.407 Å

PDB-6d85:
Structure of the Bovine p85a BH domain E217K mutant
Method: X-RAY DIFFRACTION / Resolution: 2.203 Å

PDB-6d86:
Structure of the Bovine p85a BH domain
Method: X-RAY DIFFRACTION / Resolution: 2.301 Å

PDB-6d87:
Structure of the Bovine p85alpha BH domain, R262T mutant
Method: X-RAY DIFFRACTION / Resolution: 2.7 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

Source
  • bos taurus (cattle)
KeywordsSIGNALING PROTEIN / GAP protein / E217K mutant

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