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Structure paper

TitleStructural basis for overhang excision and terminal unwinding of DNA duplexes by TREX1
Journal, issue, pagesPLoS Biol., Vol. 16, Page e2005653-e2005653, Year 2018
Publish dateNov 30, 2017 (structure data deposition date)
AuthorsHuang, K.W. / Liu, T.C. / Liang, R.Y. / Chu, L.Y. / Cheng, H.L. / Chu, J.W. / Hsiao, Y.Y.
External linksPLoS Biol. / PubMed:29734329
MethodsX-ray diffraction
Resolution1.7 - 3.4 Å
Structure data

PDB-5yws:
Crystal structure of TREX1 in complex with a Y structured DNA
Method: X-RAY DIFFRACTION / Resolution: 2 Å

PDB-5ywt:
Crystal structure of TREX1 in complex with a duplex DNA with 3' overhang
Method: X-RAY DIFFRACTION / Resolution: 1.7 Å

PDB-5ywu:
Crystal structure of TREX1 in complex with a inosine contained dsDNA
Method: X-RAY DIFFRACTION / Resolution: 3.4 Å

PDB-5ywv:
Crystal structure of TREX1 in complex with a inosine contained ssDNA
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

Chemicals

ChemComp-MG:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-CO:
Unknown entry

ChemComp-NA:
Unknown entry

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-MES:
2-(N-MORPHOLINO)-ETHANESULFONIC ACID / pH buffer*YM

Source
  • mus musculus (house mouse)
  • homo sapiens (human)
KeywordsDNA BINDING PROTEIN/DNA / DEDDh / Exouclease / Protein-DNA complex / DNA BINDING PROTEIN-DNA complex / DNA BINDING PROTEIN / TREX1 / exonuclease / DEDDh family

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