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-Structure paper
タイトル | Superinfection Drives HIV Neutralizing Antibody Responses from Several B Cell Lineages that Contribute to a Polyclonal Repertoire. |
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ジャーナル・号・ページ | Cell Rep, Vol. 23, Issue 3, Page 682-691, Year 2018 |
掲載日 | 2018年4月17日 |
著者 | Katherine L Williams / Bingjie Wang / Dana Arenz / James A Williams / Adam S Dingens / Valerie Cortez / Cassandra A Simonich / Stephanie Rainwater / Dara A Lehman / Kelly K Lee / Julie Overbaugh / |
PubMed 要旨 | Eliciting broad and potent HIV-specific neutralizing antibody responses represents the holy grail of HIV vaccine efforts. Data from singly infected individuals with broad and potent plasma ...Eliciting broad and potent HIV-specific neutralizing antibody responses represents the holy grail of HIV vaccine efforts. Data from singly infected individuals with broad and potent plasma neutralizing activity targeting one epitope have guided our understanding of how these responses develop. However, far less is known about responses developed by superinfected individuals who acquire two distinct HIV strains. Here, we isolated HIV-specific mAbs from a superinfected individual with a broad plasma response. In this superinfection case, neutralizing activity resulted from multiple distinct B cell lineages that arose in response to either the initial or the superinfecting virus, including an antibody that targets the N332 supersite. This nAb, QA013.2, was specific to the superinfecting virus and was associated with eventual reemergence of the initial infecting virus. The complex dynamic between viruses in superinfection may drive development of a unique collection of polyclonal nAbs that present a higher barrier to escape than monoclonal responses. |
リンク | Cell Rep / PubMed:29669274 / PubMed Central |
手法 | EM (単粒子) |
解像度 | 12.5 Å |
構造データ | EMDB-7471: |
由来 |
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