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TitleIn Vivo Structures of the Helicobacter pylori cag Type IV Secretion System.
Journal, issue, pagesCell Rep, Vol. 23, Issue 3, Page 673-681, Year 2018
Publish dateApr 17, 2018
AuthorsYi-Wei Chang / Carrie L Shaffer / Lee A Rettberg / Debnath Ghosal / Grant J Jensen /
PubMed AbstractThe type IV secretion system (T4SS) is a versatile nanomachine that translocates diverse effector molecules between microbes and into eukaryotic cells. Here, using electron cryotomography, we reveal ...The type IV secretion system (T4SS) is a versatile nanomachine that translocates diverse effector molecules between microbes and into eukaryotic cells. Here, using electron cryotomography, we reveal the molecular architecture of the Helicobacter pylori cag T4SS. Although most components are unique to H. pylori, the cag T4SS exhibits remarkable architectural similarity to other T4SSs. Our images revealed that, when H. pylori encounters host cells, the bacterium elaborates membranous tubes perforated by lateral ports. Sub-tomogram averaging of the cag T4SS machinery revealed periplasmic densities associated with the outer membrane, a central stalk, and peripheral wing-like densities. Additionally, we resolved pilus-like rod structures extending from the cag T4SS into the inner membrane, as well as densities within the cytoplasmic apparatus corresponding to a short central barrel surrounded by four longer barrels. Collectively, these studies reveal the structure of a dynamic molecular machine that evolved to function in the human gastric niche.
External linksCell Rep / PubMed:29669273 / PubMed Central
MethodsEM (subtomogram averaging)
Resolution39.0 - 68.0 Å
Structure data

EMDB-7474:
Subtomogram average of the cag type IV secretion system in Helicobacter pylori cells (aligning periplasmic parts)
Method: EM (subtomogram averaging) / Resolution: 39.0 Å

EMDB-7475:
Subtomogram average of the cag type IV secretion system in Helicobacter pylori cells (aligning cytoplasmic parts)
Method: EM (subtomogram averaging) / Resolution: 68.0 Å

Source
  • Helicobacter pylori (bacteria)

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