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TitleGerminal center antibody mutation trajectories are determined by rapid self/foreign discrimination.
Journal, issue, pagesScience, Vol. 360, Page 223-226, Year 2018
Publish dateApr 19, 2017 (structure data deposition date)
AuthorsBurnett, D.L. / Langley, D.B. / Schofield, P. / Hermes, J.R. / Chan, T.D. / Jackson, J. / Bourne, K. / Reed, J.H. / Patterson, K. / Porebski, B.T. ...Burnett, D.L. / Langley, D.B. / Schofield, P. / Hermes, J.R. / Chan, T.D. / Jackson, J. / Bourne, K. / Reed, J.H. / Patterson, K. / Porebski, B.T. / Brink, R. / Christ, D. / Goodnow, C.C.
External linksScience / PubMed:29650674
MethodsX-ray diffraction
Resolution1.9 - 2.43 Å
Structure data

PDB-5vjo:
Complex between HyHEL10 Fab fragment heavy chain mutant I29F and Pekin duck egg lysozyme isoform I (DEL-I)
Method: X-RAY DIFFRACTION / Resolution: 2.43 Å

PDB-5vjq:
Complex between HyHEL10 Fab fragment heavy chain mutant (I29F, S52T, Y53F) and Pekin duck egg lysozyme isoform I (DEL-I)
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

Chemicals

ChemComp-CL:
Unknown entry

ChemComp-NA:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-GOL:
GLYCEROL

Source
  • mus musculus (house mouse)
  • anas platyrhynchos (mallard)
KeywordsHYDROLASE/IMMUNE SYSTEM / lysozyme / hydrolase / HYDROLASE-IMMUNE SYSTEM complex

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