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Structure paper

TitleToll-like Receptor 9 Contains Two DNA Binding Sites that Function Cooperatively to Promote Receptor Dimerization and Activation
Journal, issue, pagesImmunity, Vol. 48, Page 649-658.e4, Year 2018
Publish dateJul 29, 2017 (structure data deposition date)
AuthorsOhto, U. / Ishida, H. / Shibata, T. / Sato, R. / Miyake, K. / Shimizu, T.
External linksImmunity / PubMed:29625894
MethodsX-ray diffraction
Resolution1.81 - 2.7 Å
Structure data

PDB-5y3j:
Crystal structure of horse TLR9 in complex with two DNAs (CpG DNA and TCGCAC DNA)
Method: X-RAY DIFFRACTION / Resolution: 1.81 Å

PDB-5y3k:
Crystal structure of horse TLR9 in complex with two DNAs (CpG DNA and GCGCAC DNA)
Method: X-RAY DIFFRACTION / Resolution: 2.7 Å

PDB-5y3l:
Crystal structure of horse TLR9 in complex with two DNAs (CpG DNA and CCGCAC DNA)
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

PDB-5y3m:
Crystal structure of bovine TLR9 in complex with two DNAs (CpG DNA and TCGTTT DNA)
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-MG:
Unknown entry

ChemComp-HOH:
WATER

Source
  • equus caballus (horse)
  • synthetic construct (others)
  • bos taurus (domestic cattle)
KeywordsIMMUNE SYSTEM / Innate immunity / Toll-like receptor / Leucine-rich repeat / DNA binding

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