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Structure paper

TitleA structurally conserved motif in gamma-herpesvirus uracil-DNA glycosylases elicits duplex nucleotide-flipping.
Journal, issue, pagesNucleic Acids Res., Vol. 46, Page 4286-4300, Year 2018
Publish dateApr 8, 2017 (structure data deposition date)
AuthorsEarl, C. / Bagneris, C. / Zeman, K. / Cole, A. / Barrett, T. / Savva, R.
External linksNucleic Acids Res. / PubMed:29596604
MethodsX-ray diffraction
Resolution2.2 - 2.97 Å
Structure data

PDB-5nn7:
KSHV uracil-DNA glycosylase, apo form
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

PDB-5nnh:
KSHV uracil-DNA glycosylase, apo form
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

PDB-5nnu:
KSHV uracil-DNA glycosylase, product complex with dsDNA exhibiting duplex nucleotide flipping
Method: X-RAY DIFFRACTION / Resolution: 2.97 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-SO4:
SULFATE ION

Source
  • human herpesvirus 8
  • synthetic construct (others)
KeywordsHYDROLASE / Uracil-DNA glycosylase

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