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TitleNew fluorescence-based high-throughput screening assay for small molecule inhibitors of tyrosyl-DNA phosphodiesterase 2 (TDP2).
Journal, issue, pagesEur J Pharm Sci, Vol. 118, Page 67-79, Year 2018
Publish dateJan 29, 2018 (structure data deposition date)
AuthorsRibeiro, C.J.A. / Kankanala, J. / Shi, K. / Kurahashi, K. / Kiselev, E. / Ravji, A. / Pommier, Y. / Aihara, H. / Wang, Z.
External linksEur J Pharm Sci / PubMed:29574079
MethodsX-ray diffraction
Resolution1.623 Å
Structure data

PDB-6ca4:
Crystal structure of humanized D. rerio TDP2 by 14 mutations
Method: X-RAY DIFFRACTION / Resolution: 1.623 Å

Chemicals

ChemComp-MG:
Unknown entry

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-MLI:
MALONATE ION

ChemComp-HOH:
WATER

Source
  • danio rerio (zebrafish)
KeywordsHYDROLASE / TDP2

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