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TitleTransposase-DNA Complex Structures Reveal Mechanisms for Conjugative Transposition of Antibiotic Resistance.
Journal, issue, pagesCell, Vol. 173, Page 208-220.e20, Year 2018
Publish dateOct 4, 2017 (structure data deposition date)
AuthorsRubio-Cosials, A. / Schulz, E.C. / Lambertsen, L. / Smyshlyaev, G. / Rojas-Cordova, C. / Forslund, K. / Karaca, E. / Bebel, A. / Bork, P. / Barabas, O.
External linksCell / PubMed:29551265
MethodsX-ray diffraction
Resolution2.5 - 2.8 Å
Structure data

PDB-6emy:
Structure of the Tn1549 transposon Integrase (aa 82-397, Y379F) in complex with transposon right end DNA
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

PDB-6emz:
Structure of the Tn1549 transposon Integrase (aa 82-397, R225K) in complex with circular intermediate DNA (CI5-DNA)
Method: X-RAY DIFFRACTION / Resolution: 2.79 Å

PDB-6en0:
Structure of the Tn1549 transposon Integrase (aa 82-397) in complex with circular intermediate DNA (CI5-DNA)
Method: X-RAY DIFFRACTION / Resolution: 2.8 Å

PDB-6en1:
Structure of the Tn1549 transposon Integrase (aa 82-397, R225K) in complex with a circular intermediate DNA (CI6a-DNA)
Method: X-RAY DIFFRACTION / Resolution: 2.67 Å

PDB-6en2:
Structure of the Tn1549 transposon Integrase (aa 82-397, R225K) in complex with a circular intermediate DNA (CI6b-DNA)
Method: X-RAY DIFFRACTION / Resolution: 2.67 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-PEG:
DI(HYDROXYETHYL)ETHER

Source
  • enterococcus faecalis (bacteria)
  • clostridioides difficile (bacteria)
KeywordsRECOMBINATION / transposase protein-DNA complex / tyrosine recombinase / Y-transposase / Tn916-like conjugative transposon / antibiotic resistance transfer / transposase protein - DNA complex

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