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TitleStructures of Teneurin adhesion receptors reveal an ancient fold for cell-cell interaction.
Journal, issue, pagesNat Commun, Vol. 9, Issue 1, Page 1079, Year 2018
Publish dateMar 14, 2018
AuthorsVerity A Jackson / Dimphna H Meijer / Maria Carrasquero / Laura S van Bezouwen / Edward D Lowe / Colin Kleanthous / Bert J C Janssen / Elena Seiradake /
PubMed AbstractTeneurins are ancient cell-cell adhesion receptors that are vital for brain development and synapse organisation. They originated in early metazoan evolution through a horizontal gene transfer event ...Teneurins are ancient cell-cell adhesion receptors that are vital for brain development and synapse organisation. They originated in early metazoan evolution through a horizontal gene transfer event when a bacterial YD-repeat toxin fused to a eukaryotic receptor. We present X-ray crystallography and cryo-EM structures of two Teneurins, revealing a ~200 kDa extracellular super-fold in which eight sub-domains form an intricate structure centred on a spiralling YD-repeat shell. An alternatively spliced loop, which is implicated in homophilic Teneurin interaction and specificity, is exposed and thus poised for interaction. The N-terminal side of the shell is 'plugged' via a fibronectin-plug domain combination, which defines a new class of YD proteins. Unexpectedly, we find that these proteins are widespread amongst modern bacteria, suggesting early metazoan receptor evolution from a distinct class of proteins, which today includes both bacterial proteins and eukaryotic Teneurins.
External linksNat Commun / PubMed:29540701 / PubMed Central
MethodsEM (single particle) / X-ray diffraction
Resolution2.38 - 3.8 Å
Structure data

4219

6fay

EMDB-4219, PDB-6fay:
Teneurin3 monomer
Method: EM (single particle) / Resolution: 3.8 Å

PDB-6fb3:
Teneurin 2 Partial Extracellular Domain
Method: X-RAY DIFFRACTION / Resolution: 2.38 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-HOH:
WATER

Source
  • mus musculus (house mouse)
  • gallus gallus (chicken)
KeywordsCELL ADHESION / Neuronal cell adhesion / bacterial toxin-like / TTR / fibronectin / FN-plug / NHL / YD-repeat / antibiotic-binding / colicin / nuclease / cell surface receptor / latrophilin / glycoprotein

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