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-Structure paper
Title | ( S)-2-Amino-3-(5-methyl-3-hydroxyisoxazol-4-yl)propanoic Acid (AMPA) and Kainate Receptor Ligands: Further Exploration of Bioisosteric Replacements and Structural and Biological Investigation. |
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Journal, issue, pages | J. Med. Chem., Vol. 61, Page 2124-2130, Year 2018 |
Publish date | Nov 23, 2017 (structure data deposition date) |
![]() | Brogi, S. / Brindisi, M. / Butini, S. / Kshirsagar, G.U. / Maramai, S. / Chemi, G. / Gemma, S. / Campiani, G. / Novellino, E. / Fiorenzani, P. ...Brogi, S. / Brindisi, M. / Butini, S. / Kshirsagar, G.U. / Maramai, S. / Chemi, G. / Gemma, S. / Campiani, G. / Novellino, E. / Fiorenzani, P. / Pinassi, J. / Aloisi, A.M. / Gynther, M. / Venskutonyte, R. / Han, L. / Frydenvang, K. / Kastrup, J.S. / Pickering, D.S. |
![]() | ![]() ![]() |
Methods | X-ray diffraction |
Resolution | 2.4 - 2.6 Å |
Structure data | ![]() PDB-6f28: ![]() PDB-6f29: |
Chemicals | ![]() ChemComp-ZN: ![]() ChemComp-CG8: ![]() ChemComp-CL: ![]() ChemComp-SO4: ![]() ChemComp-HOH: ![]() ChemComp-CGW: ![]() ChemComp-K: |
Source |
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![]() | MEMBRANE PROTEIN / ionotropic glutamate receptor / GluK3 / ligand binding domain / membrane protein. |