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Structure paper

TitleProbing Dominant Negative Behavior of Glucocorticoid Receptor beta through a Hybrid Structural and Biochemical Approach.
Journal, issue, pagesMol. Cell. Biol., Year 2018
Publish dateDec 21, 2016 (structure data deposition date)
AuthorsMin, J. / Perera, L. / Krahn, J.M. / Jewell, C.M. / Moon, A.F. / Cidlowski, J.A. / Pedersen, L.C.
External linksMol. Cell. Biol. / PubMed:29437838
MethodsX-ray diffraction
Resolution2.351 Å
Structure data

PDB-5uc1:
Structural Analysis of Glucocorticoid Receptor beta Ligand Binding Domain Complexed with Glucocorticoid Antagonist RU-486: Implication of Helix 12 in Antagonism
Method: X-RAY DIFFRACTION / Resolution: 2.351 Å

Chemicals

ChemComp-486:
11-(4-DIMETHYLAMINO-PHENYL)-17-HYDROXY-13-METHYL-17-PROP-1-YNYL-1,2,6,7,8,11,12,13,14,15,16,17-DODEC AHYDRO-CYCLOPENTA[A]PHENANTHREN-3-ONE

ChemComp-CPS:
3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE / detergent*YM

ChemComp-CL:
Unknown entry

ChemComp-MPD:
(4S)-2-METHYL-2,4-PENTANEDIOL / precipitant*YM

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-HOH:
WATER

Source
  • heterocephalus glaber (naked mole-rat)
KeywordsHORMONE RECEPTOR / Nuclear receptor

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