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Structure paper

TitleStructural basis for DNMT3A-mediated de novo DNA methylation.
Journal, issue, pagesNature, Vol. 554, Page 387-391, Year 2018
Publish dateDec 1, 2017 (structure data deposition date)
AuthorsZhang, Z.M. / Lu, R. / Wang, P. / Yu, Y. / Chen, D. / Gao, L. / Liu, S. / Ji, D. / Rothbart, S.B. / Wang, Y. ...Zhang, Z.M. / Lu, R. / Wang, P. / Yu, Y. / Chen, D. / Gao, L. / Liu, S. / Ji, D. / Rothbart, S.B. / Wang, Y. / Wang, G.G. / Song, J.
External linksNature / PubMed:29414941
MethodsX-ray diffraction
Resolution2.653 - 3.098 Å
Structure data

PDB-5yx2:
Crystal structure of DNMT3A-DNMT3L in complex with DNA containing two CpG sites
Method: X-RAY DIFFRACTION / Resolution: 2.653 Å

PDB-6brr:
Crystal structure of DNMT3A (R836A)-DNMT3L in complex with DNA containing two CpG sites
Method: X-RAY DIFFRACTION / Resolution: 2.97 Å

PDB-6f57:
Crystal structure of DNMT3A-DNMT3L in complex with single CpG-containing DNA
Method: X-RAY DIFFRACTION / Resolution: 3.098 Å

Chemicals

ChemComp-GOL:
GLYCEROL

ChemComp-SAH:
S-ADENOSYL-L-HOMOCYSTEINE

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • synthetic construct (others)
KeywordsTRANSFERASE/TRANSFERASE REGULATOR/DNA / DNMT3A / DNMT3L / DNA methylation / TRANSFERASE-TRANSFERASE REGULATOR-DNA complex / TRANSFERASE/DNA / TRANSFERASE-DNA complex / DNA binding protein

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