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TitleIncreased epitope complexity correlated with antibody affinity maturation and a novel binding mode revealed by structures of rabbit antibodies against the third variable loop (V3) of HIV-1 gp120.
Journal, issue, pagesJ. Virol., Year 2018
Publish dateMar 17, 2017 (structure data deposition date)
AuthorsPan, R. / Qin, Y. / Banasik, M. / Lees, W. / Shepherd, A.J. / Cho, M.W. / Kong, X.P.
External linksJ. Virol. / PubMed:29343576
MethodsX-ray diffraction
Resolution1.9 - 2.549 Å
Structure data

PDB-5v6l:
Crystal Structure of Rabbit Anti-HIV-1 gp120 V3 Fab 10A37 in complex with V3 peptide JR-FL
Method: X-RAY DIFFRACTION / Resolution: 2.549 Å

PDB-5v6m:
Crystal Structure of Rabbit Anti-HIV-1 gp120 V3 Fab 10A3 in complex with V3 peptide ConB
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-CA:
Unknown entry

Source
  • oryctolagus cuniculus (rabbit)
  • human immunodeficiency virus 1
KeywordsVIRAL PROTEIN/IMMUNE SYSTEM / HIV / gp120 / V3 / Antibody / VIRAL PROTEIN-IMMUNE SYSTEM complex

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