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TitleMemory B Cells that Cross-React with Group 1 and Group 2 Influenza A Viruses Are Abundant in Adult Human Repertoires.
Journal, issue, pagesImmunity, Vol. 48, Page 174-184.e9, Year 2018
Publish dateMay 30, 2017 (structure data deposition date)
AuthorsMcCarthy, K.R. / Watanabe, A. / Kuraoka, M. / Do, K.T. / McGee, C.E. / Sempowski, G.D. / Kepler, T.B. / Schmidt, A.G. / Kelsoe, G. / Harrison, S.C.
External linksImmunity / PubMed:29343437
MethodsX-ray diffraction
Resolution1.899 - 2.6 Å
Structure data

PDB-5w08:
A/Texas/50/2012(H3N2) Influenza hemagglutinin in complex with K03.12 Fab
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

PDB-5w0d:
Inferred precursor (UCA) of the human antibody lineage K03.12 in complex with influenza hemagglutinin H1 Solomon Islands/03/2006
Method: X-RAY DIFFRACTION / Resolution: 1.899 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

ChemComp-MES:
2-(N-MORPHOLINO)-ETHANESULFONIC ACID / pH buffer*YM

Source
  • influenza a virus (a/texas/50/2012(h3n2))
  • homo sapiens (human)
  • influenza a virus (a/solomon islands/3/2006(h1n1))
KeywordsVIRAL PROTEIN/IMMUNE SYSTEM / Fab influenza neutralizing antibody / VIRAL PROTEIN-IMMUNE SYSTEM complex / influenza neutralizing antibody germline precursor

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