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Structure paper

TitleRole for first zinc finger of WT1 in DNA sequence specificity: Denys-Drash syndrome-associated WT1 mutant in ZF1 enhances affinity for a subset of WT1 binding sites.
Journal, issue, pagesNucleic Acids Res., Vol. 46, Page 3864-3877, Year 2018
Publish dateSep 14, 2017 (structure data deposition date)
AuthorsWang, D. / Horton, J.R. / Zheng, Y. / Blumenthal, R.M. / Zhang, X. / Cheng, X.
External linksNucleic Acids Res. / PubMed:29294058
MethodsX-ray diffraction
Resolution1.552 - 2.794 Å
Structure data

PDB-6b0o:
Zinc finger Domain of WT1(-KTS form) with 12+1mer Oligonucleotide with 3' Triplet TGT
Method: X-RAY DIFFRACTION / Resolution: 1.552 Å

PDB-6b0p:
Zinc finger Domain of WT1(-KTS form) with 12+1mer Oligonucleotide with 3' Triplet GGT
Method: X-RAY DIFFRACTION / Resolution: 2.077 Å

PDB-6b0q:
Zinc finger Domain of WT1(-KTS form) with 13+1mer Oligonucleotide with 3' Triplet TGT
Method: X-RAY DIFFRACTION / Resolution: 2.794 Å

PDB-6b0r:
Zinc finger Domain of WT1(-KTS form) with M342R Mutation and 14+1mer Oligonucleotide with 3' Triplet TGG
Method: X-RAY DIFFRACTION / Resolution: 1.818 Å

PDB-6blw:
Zinc finger Domain of WT1(+KTS form) with M342R Mutation and 17+1mer Oligonucleotide with Triplet GGT
Method: X-RAY DIFFRACTION / Resolution: 1.835 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-HOH:
WATER

ChemComp-SO4:
SULFATE ION

ChemComp-GOL:
GLYCEROL

Source
  • homo sapiens (human)
KeywordsTRANSCRIPTION/DNA / protein-DNA complex Wilms tumor suppressor protein zinc-fingers / TRANSCRIPTION-DNA complex / DNA BINDING PROTEIN/DNA / DNA BINDING PROTEIN-DNA complex

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