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TitleMolecular structure of human KATP in complex with ATP and ADP.
Journal, issue, pagesElife, Vol. 6, Year 2017
Publish dateDec 29, 2017
AuthorsKenneth Pak Kin Lee / Jue Chen / Roderick MacKinnon /
PubMed AbstractIn many excitable cells, KATP channels respond to intracellular adenosine nucleotides: ATP inhibits while ADP activates. We present two structures of the human pancreatic KATP channel, containing the ...In many excitable cells, KATP channels respond to intracellular adenosine nucleotides: ATP inhibits while ADP activates. We present two structures of the human pancreatic KATP channel, containing the ABC transporter SUR1 and the inward-rectifier K channel Kir6.2, in the presence of Mg and nucleotides. These structures, referred to as quatrefoil and propeller forms, were determined by single-particle cryo-EM at 3.9 Å and 5.6 Å, respectively. In both forms, ATP occupies the inhibitory site in Kir6.2. The nucleotide-binding domains of SUR1 are dimerized with Mg-ATP in the degenerate site and Mg-ADP in the consensus site. A lasso extension forms an interface between SUR1 and Kir6.2 adjacent to the ATP site in the propeller form and is disrupted in the quatrefoil form. These structures support the role of SUR1 as an ADP sensor and highlight the lasso extension as a key regulatory element in ADP's ability to override ATP inhibition.
External linksElife / PubMed:29286281 / PubMed Central
MethodsEM (single particle)
Resolution3.9 - 5.6 Å
Structure data

7338

6c3o

EMDB-7338, PDB-6c3o:
Cryo-EM structure of human KATP bound to ATP and ADP in quatrefoil form
Method: EM (single particle) / Resolution: 3.9 Å

7339

6c3p

EMDB-7339, PDB-6c3p:
Cryo-EM structure of human KATP bound to ATP and ADP in propeller form
Method: EM (single particle) / Resolution: 5.6 Å

Chemicals

ChemComp-ATP:
ADENOSINE-5'-TRIPHOSPHATE / ATP, energy-carrying molecule*YM / Adenosine triphosphate

ChemComp-K:
Unknown entry

ChemComp-ADP:
ADENOSINE-5'-DIPHOSPHATE / ADP, energy-carrying molecule*YM / Adenosine diphosphate

ChemComp-MG:
Unknown entry

Source
  • homo sapiens (human)
KeywordsTRANSPORT PROTEIN / ATP-dependent potassium channel Kir6.2 SUR1 ATP ADP

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