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-Structure paper
Title | Crystal Structures and Inhibitor Interactions of Mouse and Dog MTH1 Reveal Species-Specific Differences in Affinity. |
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Journal, issue, pages | Biochemistry, Vol. 57, Page 593-603, Year 2018 |
Publish date | Jan 31, 2017 (structure data deposition date) |
Authors | Narwal, M. / Jemth, A.S. / Gustafsson, R. / Almlof, I. / Warpman Berglund, U. / Helleday, T. / Stenmark, P. |
External links | Biochemistry / PubMed:29281266 |
Methods | X-ray diffraction |
Resolution | 1.85 - 2.4 Å |
Structure data | PDB-5mze: PDB-5mzf: PDB-5mzg: PDB-6ehh: |
Chemicals | ChemComp-CU: ChemComp-PEG: ChemComp-8DG: ChemComp-GOL: ChemComp-HOH: ChemComp-SO4: ChemComp-ACT: ChemComp-CL: ChemComp-2GE: ChemComp-SCN: ChemComp-NO3: ChemComp-MG: |
Source |
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Keywords | HYDROLASE / substrate / complex / drug target / Inhibitor / mutant / MTH1 / mouse |