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-Structure paper
Title | Discovery and Optimization of Thiazolidinyl and Pyrrolidinyl Derivatives as Inhaled PDE4 Inhibitors for Respiratory Diseases. |
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Journal, issue, pages | J. Med. Chem., Vol. 60, Page 10026-10046, Year 2017 |
Publish date | Jul 17, 2017 (structure data deposition date) |
Authors | Carzaniga, L. / Amari, G. / Rizzi, A. / Capaldi, C. / De Fanti, R. / Ghidini, E. / Villetti, G. / Carnini, C. / Moretto, N. / Facchinetti, F. ...Carzaniga, L. / Amari, G. / Rizzi, A. / Capaldi, C. / De Fanti, R. / Ghidini, E. / Villetti, G. / Carnini, C. / Moretto, N. / Facchinetti, F. / Caruso, P. / Marchini, G. / Battipaglia, L. / Patacchini, R. / Cenacchi, V. / Volta, R. / Amadei, F. / Pappani, A. / Capacchi, S. / Bagnacani, V. / Delcanale, M. / Puccini, P. / Catinella, S. / Civelli, M. / Armani, E. |
External links | J. Med. Chem. / PubMed:29200281 |
Methods | X-ray diffraction |
Resolution | 1.6 Å |
Structure data | PDB-5ohj: |
Chemicals | ChemComp-ZN: ChemComp-MG: ChemComp-9VE: ChemComp-HOH: |
Source |
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Keywords | HYDROLASE / human phosphodiesterase 4B / pyrrolidinyl inhibitor / PDE4B |