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-Structure paper
Title | A Potent, Metabolically Stable Tubulin Inhibitor Targets the Colchicine Binding Site and Overcomes Taxane Resistance. |
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Journal, issue, pages | Cancer Res., Vol. 78, Page 265-277, Year 2018 |
Publish date | Nov 20, 2016 (structure data deposition date) |
Authors | Arnst, K.E. / Wang, Y. / Hwang, D.J. / Xue, Y. / Costello, T. / Hamilton, D. / Chen, Q. / Yang, J. / Park, F. / Dalton, J.T. ...Arnst, K.E. / Wang, Y. / Hwang, D.J. / Xue, Y. / Costello, T. / Hamilton, D. / Chen, Q. / Yang, J. / Park, F. / Dalton, J.T. / Miller, D.D. / Li, W. |
External links | Cancer Res. / PubMed:29180476 |
Methods | X-ray diffraction |
Resolution | 2.8 Å |
Structure data | PDB-5h7o: |
Chemicals | ChemComp-GTP: ChemComp-MG: ChemComp-CA: ChemComp-GOL: ChemComp-GDP: ChemComp-MES: ChemComp-7Q7: ChemComp-ACP: ChemComp-HOH: |
Source |
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Keywords | STRUCTURAL PROTEIN / DJ-101 / colchicine site tubulin inhibitor / tubulin / taxane resistance |