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Structure paper

TitleRare PfCSP C-terminal antibodies induced by live sporozoite vaccination are ineffective against malaria infection.
Journal, issue, pagesJ. Exp. Med., Vol. 215, Page 63-75, Year 2018
Publish dateSep 15, 2017 (structure data deposition date)
AuthorsScally, S.W. / Murugan, R. / Bosch, A. / Triller, G. / Costa, G. / Mordmuller, B. / Kremsner, P.G. / Sim, B.K.L. / Hoffman, S.L. / Levashina, E.A. ...Scally, S.W. / Murugan, R. / Bosch, A. / Triller, G. / Costa, G. / Mordmuller, B. / Kremsner, P.G. / Sim, B.K.L. / Hoffman, S.L. / Levashina, E.A. / Wardemann, H. / Julien, J.P.
External linksJ. Exp. Med. / PubMed:29167197
MethodsX-ray diffraction
Resolution1.9 - 1.95 Å
Structure data

PDB-6b0s:
Crystal structure of circumsporozoite protein aTSR domain in complex with 1710 antibody
Method: X-RAY DIFFRACTION / Resolution: 1.95 Å

PDB-6b0w:
Crystal structure of the anti-circumsporozoite protein 1710 antibody
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

Chemicals

ChemComp-GOL:
GLYCEROL

ChemComp-IPA:
ISOPROPYL ALCOHOL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • plasmodium falciparum (malaria parasite P. falciparum)
KeywordsIMMUNE SYSTEM / Malaria / Circumsporozoite protein / alpha thrombospondin type-1 repeat

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