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TitleAnti-SIRP alpha antibody immunotherapy enhances neutrophil and macrophage antitumor activity.
Journal, issue, pagesProc. Natl. Acad. Sci. U.S.A., Vol. 114, Page E10578-E10585, Year 2017
Publish dateNov 3, 2017 (structure data deposition date)
AuthorsRing, N.G. / Herndler-Brandstetter, D. / Weiskopf, K. / Shan, L. / Volkmer, J.P. / George, B.M. / Lietzenmayer, M. / McKenna, K.M. / Naik, T.J. / McCarty, A. ...Ring, N.G. / Herndler-Brandstetter, D. / Weiskopf, K. / Shan, L. / Volkmer, J.P. / George, B.M. / Lietzenmayer, M. / McKenna, K.M. / Naik, T.J. / McCarty, A. / Zheng, Y. / Ring, A.M. / Flavell, R.A. / Weissman, I.L.
External linksProc. Natl. Acad. Sci. U.S.A. / PubMed:29158380
MethodsX-ray diffraction
Resolution2.191 Å
Structure data

PDB-6bit:
SIRPalpha antibody complex
Method: X-RAY DIFFRACTION / Resolution: 2.191 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • mus musculus (house mouse)
KeywordsIMMUNE SYSTEM / Macrophage / Neutrophil / Phagocytosis / Myeloid / Immune checkpoint / CD47 / SIRP / Cancer immunotherapy

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