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TitleTargeting SxIP-EB1 interaction: An integrated approach to the discovery of small molecule modulators of dynamic binding sites.
Journal, issue, pagesSci Rep, Vol. 7, Page 15533-15533, Year 2017
Publish dateNov 1, 2017 (structure data deposition date)
AuthorsAlmeida, T.B. / Carnell, A.J. / Barsukov, I.L. / Berry, N.G.
External linksSci Rep / PubMed:29138501
MethodsNMR (solution)
Structure data

PDB-6evi:
solution NMR structure of EB1 C terminus (191-260)
Method: SOLUTION NMR

PDB-6evq:
solution NMR structure of EB1 C terminus (191-260) with a small molecule bound into the SxIP binding site
Method: SOLUTION NMR

Chemicals

ChemComp-C05:
(2~{R})-2-[(1-cyclopentyl-1,2,3,4-tetrazol-5-yl)sulfanyl]-~{N}-(furan-2-ylmethyl)propanamide

Source
  • mus musculus (house mouse)
KeywordsPROTEIN BINDING / End-binding protein / EB1 / microtubules / SxIP / Microtubule-associated protein RP/EB family member 1 / MAPRE1 / APC-binding protein EB1

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