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TitleA glycerophospholipid-specific pocket in the RVFV class II fusion protein drives target membrane insertion.
Journal, issue, pagesScience, Vol. 358, Page 663-667, Year 2017
Publish dateSep 12, 2017 (structure data deposition date)
AuthorsGuardado-Calvo, P. / Atkovska, K. / Jeffers, S.A. / Grau, N. / Backovic, M. / Perez-Vargas, J. / de Boer, S.M. / Tortorici, M.A. / Pehau-Arnaudet, G. / Lepault, J. ...Guardado-Calvo, P. / Atkovska, K. / Jeffers, S.A. / Grau, N. / Backovic, M. / Perez-Vargas, J. / de Boer, S.M. / Tortorici, M.A. / Pehau-Arnaudet, G. / Lepault, J. / England, P. / Rottier, P.J. / Bosch, B.J. / Hub, J.S. / Rey, F.A.
External linksScience / PubMed:29097548
MethodsX-ray diffraction
Resolution2.3 - 2.5 Å
Structure data

PDB-6egt:
Structure of RVFV envelope protein Gc in postfusion conformation in complex with MES
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

PDB-6egu:
Structure of RVFV envelope protein Gc in postfusion conformation in complex with 1,2-dipropionyl-sn-glycero-3-phosphocholine
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-MES:
2-(N-MORPHOLINO)-ETHANESULFONIC ACID / pH buffer*YM

ChemComp-HOH:
WATER

ChemComp-43Y:
[(2R)-3-[oxidanyl-[2-(trimethyl-$l^{4}-azanyl)ethoxy]phosphoryl]oxy-2-propanoyloxy-propyl] propanoate

Source
  • rift valley fever virus
KeywordsVIRAL PROTEIN / fusion protein viral envelope lipid interaction viral fusion / viral fusion envelope glycoprotein bunyavirus phlebovirus

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