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Structure paper

TitleSAV1 promotes Hippo kinase activation through antagonizing the PP2A phosphatase STRIPAK.
Journal, issue, pagesElife, Vol. 6, Year 2017
Publish dateAug 15, 2017 (structure data deposition date)
AuthorsBae, S.J. / Ni, L. / Osinski, A. / Tomchick, D.R. / Brautigam, C.A. / Luo, X.
External linksElife / PubMed:29063833
MethodsX-ray diffraction
Resolution1.08 - 2.955 Å
Structure data

PDB-6ao5:
Crystal structure of human MST2 in complex with SAV1 SARAH domain
Method: X-RAY DIFFRACTION / Resolution: 2.955 Å

PDB-6ar0:
Structure of human SLMAP FHA domain
Method: X-RAY DIFFRACTION / Resolution: 1.08 Å

PDB-6ar2:
Structure of human SLMAP FHA domain in complex with pMST2
Method: X-RAY DIFFRACTION / Resolution: 1.55 Å

Chemicals

ChemComp-ANP:
PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER / AMP-PNP, energy-carrying molecule analogue*YM

ChemComp-MG:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsSIGNALING PROTEIN / Hippo / mst autoactivation / dimerization / SLMAP / FHA / MEMBRANE PROTEIN / phospho-MST2

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