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-Structure paper
Title | The small molecule luteolin inhibits N-acetyl-alpha-galactosaminyltransferases and reduces mucin-type O-glycosylation of amyloid precursor protein. |
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Journal, issue, pages | J. Biol. Chem., Vol. 292, Page 21304-21319, Year 2017 |
Publish date | Mar 8, 2017 (structure data deposition date) |
Authors | Liu, F. / Xu, K. / Xu, Z. / de Las Rivas, M. / Wang, C. / Li, X. / Lu, J. / Zhou, Y. / Delso, I. / Merino, P. ...Liu, F. / Xu, K. / Xu, Z. / de Las Rivas, M. / Wang, C. / Li, X. / Lu, J. / Zhou, Y. / Delso, I. / Merino, P. / Hurtado-Guerrero, R. / Zhang, Y. / Wu, F. |
External links | J. Biol. Chem. / PubMed:29061849 |
Methods | X-ray diffraction |
Resolution | 2.3 Å |
Structure data | PDB-5ndf: |
Chemicals | ChemComp-MN: ChemComp-UDP: ChemComp-EDO: ChemComp-LU2: ChemComp-HOH: |
Source |
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Keywords | TRANSFERASE / GalNAc-T2 Inhibition Flavonoids Mucin-type O-glycosylation Alzheimer disease |