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TitleThe small molecule luteolin inhibits N-acetyl-alpha-galactosaminyltransferases and reduces mucin-type O-glycosylation of amyloid precursor protein.
Journal, issue, pagesJ. Biol. Chem., Vol. 292, Page 21304-21319, Year 2017
Publish dateMar 8, 2017 (structure data deposition date)
AuthorsLiu, F. / Xu, K. / Xu, Z. / de Las Rivas, M. / Wang, C. / Li, X. / Lu, J. / Zhou, Y. / Delso, I. / Merino, P. ...Liu, F. / Xu, K. / Xu, Z. / de Las Rivas, M. / Wang, C. / Li, X. / Lu, J. / Zhou, Y. / Delso, I. / Merino, P. / Hurtado-Guerrero, R. / Zhang, Y. / Wu, F.
External linksJ. Biol. Chem. / PubMed:29061849
MethodsX-ray diffraction
Resolution2.3 Å
Structure data

PDB-5ndf:
Small-molecule inhibition of ppGalNAc-Ts selectively reduces mucin-type O-glycosylation
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

Chemicals

ChemComp-MN:
Unknown entry

ChemComp-UDP:
URIDINE-5'-DIPHOSPHATE / UDP*YM

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-LU2:
2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / GalNAc-T2 Inhibition Flavonoids Mucin-type O-glycosylation Alzheimer disease

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