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TitleCharacterization and structural determination of a new anti-MET function-blocking antibody with binding epitope distinct from the ligand binding domain.
Journal, issue, pagesSci Rep, Vol. 7, Page 9000-9000, Year 2017
Publish dateSep 5, 2016 (structure data deposition date)
AuthorsDiCara, D.M. / Chirgadze, D.Y. / Pope, A.R. / Karatt-Vellatt, A. / Winter, A. / Slavny, P. / van den Heuvel, J. / Parthiban, K. / Holland, J. / Packman, L.C. ...DiCara, D.M. / Chirgadze, D.Y. / Pope, A.R. / Karatt-Vellatt, A. / Winter, A. / Slavny, P. / van den Heuvel, J. / Parthiban, K. / Holland, J. / Packman, L.C. / Mavria, G. / Hoffmann, J. / Birchmeier, W. / Gherardi, E. / McCafferty, J.
External linksSci Rep / PubMed:28827556
MethodsX-ray diffraction
Resolution2.605 Å
Structure data

PDB-5lsp:
107_A07 Fab in complex with fragment of the Met receptor
Method: X-RAY DIFFRACTION / Resolution: 2.605 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / Fab / beta propeller / Ig-like domain / cell signalling / Met receptor / antibody binding

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