タイトル | Beyond the BET Family: Targeting CBP/p300 with 4-Acyl Pyrroles. |
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ジャーナル・号・ページ | Angew. Chem. Int. Ed. Engl., Vol. 56, Page 12476-12480, Year 2017 |
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掲載日 | 2016年8月13日 (構造データの登録日) |
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著者 | Hugle, M. / Lucas, X. / Ostrovskyi, D. / Regenass, P. / Gerhardt, S. / Einsle, O. / Hau, M. / Jung, M. / Breit, B. / Gunther, S. / Wohlwend, D. |
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リンク | Angew. Chem. Int. Ed. Engl. / PubMed:28766825 |
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手法 | X線回折 |
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解像度 | 1.5 - 2.1 Å |
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構造データ | PDB-5lpj: Crystal structure of the bromodomain of human CREBBP bound to the inhibitor XDM1 手法: X-RAY DIFFRACTION / 解像度: 1.65 Å PDB-5lpk: Crystal structure of the bromodomain of human EP300 bound to the inhibitor XDM1 手法: X-RAY DIFFRACTION / 解像度: 2.1 Å PDB-5lpl: Crystal structure of the bromodomain of human CREBBP bound to the inhibitor XDM3c 手法: X-RAY DIFFRACTION / 解像度: 1.65 Å PDB-5lpm: Crystal structure of the bromodomain of human Ep300 bound to the inhibitor XDM3d 手法: X-RAY DIFFRACTION / 解像度: 1.5 Å PDB-5nrw: Crystal structure of the human bromodomain of CREBBP bound to the inhibitor XDM4 手法: X-RAY DIFFRACTION / 解像度: 1.7 Å PDB-5nu3: Crystal structure of the human bromodomain of CREBBP bound to the inhibitor XDM-CBP 手法: X-RAY DIFFRACTION / 解像度: 1.75 Å PDB-5nu5: Crystal structure of the human bromodomain of EP300 bound to the inhibitor XDM-CBP 手法: X-RAY DIFFRACTION / 解像度: 1.6 Å |
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化合物 | ChemComp-XDM: ~{N}-[(3-chlorophenyl)methyl]-4-ethanoyl-3-ethyl-5-methyl-1~{H}-pyrrole-2-carboxamide
ChemComp-71X: ~{N}-[(1~{R},2~{R})-7-chloranyl-2-oxidanyl-1,2,3,4-tetrahydronaphthalen-1-yl]-4-ethanoyl-3-ethyl-5-methyl-1~{H}-pyrrole-2-carboxamide
ChemComp-71Y: ~{N}-[(1~{S},2~{S})-7-chloranyl-2-oxidanyl-1,2,3,4-tetrahydronaphthalen-1-yl]-4-ethanoyl-3-ethyl-5-methyl-1~{H}-pyrrole
ChemComp-96N: 4-ethanoyl-3-ethyl-5-methyl-~{N}-(naphthalen-1-ylmethyl)-1~{H}-pyrrole-2-carboxamide
ChemComp-99E: ~{N}-[[2,8-bis(oxidanyl)naphthalen-1-yl]methyl]-4-ethanoyl-3-ethyl-5-methyl-1~{H}-pyrrole-2-carboxamide
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由来 | homo sapiens (ヒト)
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キーワード | TRANSCRIPTION / bromodomain / protein-inhibitor complex / epigenetics / CBP / TRANSFERASE / CREBBP / EP300 |
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